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Batroxobin maranhao (Botrops atrox)

Description:
Batroxobin is a thrombin-like proteolytic enzyme isolated from the venom of Bothrops atrox. It splits the 16 Arg-17 Gly bond in the Aα-chain of fibrinogen and causes the release of fibrinopeptide A and the formation of fibrin I monomer or Des-AA-monomer which spontaneously aggregates into a clot of fibrin I. Batroxobin also induces the release of tPA from endothelium.

Application:
Due to its specific action on fibrinogen and its ability to clot platelet-rich plasma without affecting the integrity and functions of the platelets, and thanks to its insensitivity to thrombin inhibitors, batroxobin has found several applications as a tool in blood coagulation research and diagnosis. Batroxobin can be used to determine fibrinogen in plasma, to measure the batroxobin clotting time (Reptilase® time) as a heparin-insensitive parallel to the thrombin time, to investigate dysfibrinogenemia, and to test the contractile system of platelets.

Origin:  Bothrops atrox snake venom 

MW:  approx. 43’000 

Storage:
May be used by the expiry date given on the label when stored unopened, protected from moisture. Avoid contamination of the reagents by micro-organisms. 
Shipment of product does not require cooling during the time of transportation. Vial 100 BU/vial 2°-8°C

Category: Research use only

Type: Snake Venom Protease Activator

Product Availability: Germany, Israel and Egypt

Manufacturer: DSM Nutritional Products Ltd. Branch Pentapharm, Switzerland


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Batroxobin maranhao (Botrops atrox)

100 BU/vial
Artikelnr.: 810104

Einheit: 1 vial

Code: 101-04

Hersteller: DSM Nutritional Products Ltd. Branch Pentapharm

References:
 
  1. Stocker K. 
    Application of snake venom proteins in the diagnosis of hemostatic disorders. In: Medical Use of Snake Venom Proteins, Stocker K, ed. Boca Raton: CRC-Press 1990; 213-52.

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