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Hirudin (rec-Hirudin)

Hirudin is the most potent and specific thrombin inhibitor known. It forms a stable equimolar complex with thrombin. The complete structure of hirudin has been elucidated [Dodt et al., 1984] and a gene coding for hirudin was subsequently synthesized and expressed in yeast [Meyhack et al., 1987] and other micro-organisms. The amino acid sequence of recombinant hirudin (r-Hirudin, [Leu1, Thr2]-63-desulfatohirudin) corresponds to natural hirudin except for the substitution of leucine for isoleucine at the N-terminal end of the molecule and the absence of a sulfate group on the tyrosine at position 63.

r-Hirudin can be utilised for many analytical and preparative purposes in hemostaseological test procedures as well as in blood and plasma fractionation to block the multiple enzymatic and non­enzymatic actions of thrombin. r-Hirudin may be added to test mixtures to exclude undesired thrombin actions due to contaminations of reagents with prothrombin or with prothrombin activators.

Formula: C287H440N80O110S6

MW: 6979.5

May be used by the expiry date given on the label when stored unopened, protected from moisture, in the dark, 2°-8°C. Avoid contamination of the reagents by micro-organisms. Shipment of product does not require cooling during the time of transportation.

Note: r-Hirudin is to be used for in vitro diagnostic purposes only.

Category: Research use only

Type: Inhibitor

Product Availability: Germany, Israel and Egypt

Manufacturer: DSM Nutritional Products Ltd. Branch Pentapharm, Switzerland

For more information please click .pdf icon below.

Hirudin (rec-Hirudin)

2'000 ATU/vial
Artikelnr.: 812605/1

Einheit: 1 vial

Code: 126-10

Hersteller: DSM Nutritional Products Ltd. Branch Pentapharm


  1. Dodt J, Müller HP, Seemüller U, Chang JY.
    The complete amino acid sequence of hirudin, a thrombin specific inhibitor, application of colour Carboxymethylation.
    FEBS Lett 1984; 165: 180-4.
  2. Meyhack B, Heim J, Rink H, Zimmermann W, Maerki W.
    Desulfatohirudin, a specific thrombin inhibitor: expression and secretion in yeast.
    Thromb Res 1987; Suppl. 7: 33
  3. Svendsen L, Brogli M, Lindeberg G, Stocker K.
    Differentiation of thrombin-and factor Xa-related amidolytic activity in plasma by means of a synthetic thrombin inhibitor.
    Thromb Res 1984; 34: 457-62.
  4. Stocker K.
    Laboratory use of Hirudin.
    Seminars in Thromb and Hemostasis 1991; 17: 113-121
  5. Stocker K.
    Hirudin for diagnostic purposes.
    Haemostasis 1991; 21 (suppl1): 161-167

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