Pefabloc® TH, Inhibitor for Thrombin/NAPAP
The benzamidine moiety is a key structure for the development of inhibitors of trypsin-like enzymes. It mimics the protonated side-chain of the basic amino acids Arg and Lys which is hydrolysed by these enzymes. Pefabloc®TH (NAPAP) is one of the most potent and selective competitive inhibitors of thrombin.
Pefabloc®TH can be used in diagnostic systems, analytical applications, research and industrial purification processes to exclude undesired thrombin activity. It can also be used as a potent anticoagulant in in vitro test systems.
Formula: C27H31O4N5S · AcOH
Nα-(2-Naphthylsulfonylglycyl)-4-amidino-(D,L)-phenylalanine piperidide acetate (NAPAP)
Solubility: 1.5 mg/ml (2.6 mM) in H2O
May be used by the expiry date given on the label when stored unopened, protected from moisture, in the dark, 2-8°C. Avoid contamination of the reagents by micro-organisms. Shipment of product does not require cooling during the time of transportation.
Ki values for the inhibition of several trypsin-like serine proteases by Pefabloc®TH
|Batroxobin (B. atrox)
|Batroxobin (B. moojeni)
Category: Research use only
Product Availability: Germany, Israel and Egypt
Manufacturer: DSM Nutritional Products Ltd. Branch Pentapharm, Switzerland
For more information please click .pdf icon below.
Inhibitor for Thrombin/NAPAP
Einheit: 5 mg
Hersteller: DSM Nutritional Products Ltd. Branch Pentapharm
- Stürzebecher J, Walsmann P, Voigt B, Wagner G.
Inhibition of bovine and human thrombins by derivatives of benzamidine. Thromb Res 1984; 36: 457-65.