anti-human CD41, Clone MEM-06
Description
CD41 (platelet glycoprotein IIb) is composed of two subunits (120 kDa a, a and 23 kDa b, ß) that interact with CD61 in the presence of calcium to form a functional adhesive protein receptor. Upon blood vessel damage, this receptor binds to a variety of proteins including von Willebrand factor, fibrinogen, fibronectin and vitronectin. CD41 is mainly expressed on megakaryocyte-platelet lineage, but generally belongs to the antigens that are expressed during early stages of hematopoietic differentiation.
Properties
The monoclonal antibody ADG5026/L (clone MEM-06) is a murine monoclonal antibody, subclass IgG1. The antibody has been purified from by protein-A affinity chromatography, Purity > 95% (by SDS-PAGE). The antibody reacts with CD41 (GPIIb), a transmembrane glycoprotein (integrin family) composed of two chains GPIIbalpha (heavy chain; 120 kDa) and GPIIbß (light chain; 23 kDa). CD41 is mainly expressed on platelets and megakaryocytes.
Presentation
Vial containing 100 µg /100 µl (ADG5026) or 300 µg/ 300 µl (ADG5026L) of purified antibody in PBS containing 0.09 % sodium azide (pH 7.2). The IgG concentration is 1 mg/ml. Spin the vial briefly before opening.
Storage and Stability
Store at 4 °C. For longterm storage aliquot and store at -20°. It is recommended to avoid freeze-thaw cycles. The reagent is stable until the expiry date stated on the vial label.
Applications
Flow Cytometry
Category: Research use only
Type: Antibody
Product Availability: Worldwide
Manufacturer: ImmBioMed GmbH & Co KG, Germany
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anti-human CD41, Clone MEM-06
Cat.No. ADG5026L
Artikelnr.: 938055
Einheit: 300 µg
Code: ADG5026L
Hersteller: ImmBioMed GmbH & Co. KG
References
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- MitjavilaGarcia MT, Cailleret M, Godin I, Nogueira MM, CohenSolal K, Schiavon V, Lecluse Y, Le Pesteur F, Lagrue AH, Vainchenker W: Development. 2002 Apr;129(8):2003-13.
- Ferkowicz MJ, Starr M, Xie X, Li W, Johnson SA, Shelley WC, Morrison PR, Yoder MC: Development. 2003 Sep;130(18):4393-403.
- Zhang J, Varas F, Stadtfeld M, Heck S, Faust N, Graf
T: Exp Hematol. 2007 Mar;35(3):490-499.