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Synthetic Inhibitor of Fibrin Polymerization

The synthetic inhibitor binds with a high affinity to fibrinogen, inhibits fibrin polymerization, modifies the mechanical properties of fibrin clots and can dissociate non-stabilized fibrin gels.

Formula: H-Gly-Pro-Arg-Pro-OH×AcOH
MW: 485.5
Solubility: readily soluble in water

The inhibitor is added to fibrinogen containing reaction mixtures to inhibit disturbing fibrin-related turbidity, gel formation and fibrin deposition in diagnostic and preparative procedures (e.g. measurement of thrombin generation in plasma). The inhibitor is also used to inhibit fibrin formation during purification and processing of clotting factors and other plasma proteins.

Recommended inhibitor concentrations
Gelation prevention:
des-AB-fibrin: concentration 0.5-2.3 mM
des-A-fibrin: concentration 2.3 mM
human plasma, HC-II test: concentration 0.5 mg/ml
bov. fibrinogen 0.2% / thrombin 0.5 U/ml: concentration 1.5 mg/ml
Clot liquefaction:
des-AB-fibrin: concentration 15.0 mM
des-A-fibrin: concentration 1.0 mM

Vial containing 50 mg lyophilized inhibitor.

Reconstitute with filtered deionized water.

Storage and Stability
May be used by the expiry date given on the label when stored unopened, protected from moisture, in the dark, 2-8°C. Avoid contamination of the reagents by micro-organisms. Shipment of product does not require cooling during the time of transportation.

Research use only

Type: Inhibitor

Product Availability: Worldwide

Manufacturer: ImmBioMed GmbH & Co KG, Germany

For more information please click .pdf icon below.

Synthetic Inhibitor of Fibrin Polymerization

Cat.No. ADG4530N
Artikelnr.: 938505

Einheit: 50 mg

Code: ADG4530N

Hersteller: ImmBioMed GmbH & Co. KG


  1. Effect of calcium and synthetic peptides on fibrin polymerization. Furlan M et al., Thromb Haemost 1982; 47: 118-21.
  2. The ability of thrombin inhibitors to reduce the thrombin activity generated in plasma on extrinsic and intrinsic Activation. Prasa Det al., Thromb Haemost 1997; 77: 498-503.

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