Tel.: +49 6221 868023
Fax: +49 6221 8680255

murine MAb against CihC of Borrelia recurrentis, Clone Brk2-47.1/BR2

Borrelia recurrentis, the causal agent of louse-borne relapsing fever is transmitted to humans via infected body lice. Infection with B. recurrentis has been achieved only in humans and is accompanied by a systemic inflammatory disease, multiple relapses of fever and massive spirochetemia. A key virulence factor of B. recurrentis is their potential to undergo antigenic variation. In addition, B. recurrentis express a surface lipoprotein, termed CihC, and acquire C4b-binding protein (C4bp) and human C1 esterase inhibitor (C1-Inh), the major inhibitors of the classical and lectin pathway of complement activation to effectively evade innate and adaptive immunity.

The monoclonal antibody ADG0160L (Brk2-47.1/BR2) is a murine monoclonal antibody, subclass IgG1 recognizing CihC of Borrelia recurrentis strain A1. Mice were immunized with rec. CihC. The antibody has been purified from cell culture supernatant using Protein G affinity chromatography.

Screw capped vial containing 1 mg of purified antibody in PBS pH 7.4. The IgG concentration is given on the vial label. Spin the vial briefly before opening.

Storage and Stability
Store the antibody at 2°-8°C. For long-term storage the antibody should be aliquoted and stored at –20°C or colder. It is recommended to avoid freeze-thaw cycles.

The antibody can be used as capture antibody in ELISAs. An antibody concentration of 1-10 µg/ml is recommended.
The antibody is suitable for Western blot analysis, detecting native and recombinant CihC following SDS-PAGE under reducing conditions. A primary antibody concentration of 1-10 µg/mL is recommended.
The antibody can be used for immunocytochemistry on paraformaldehyde fixed spirochetes.

Category: Research use only

Type: Antibody

Product Availability: Worldwide

Manufacturer: ImmBioMed GmbH & Co KG, Germany

For more information please click .pdf icon below.

murine MAb against CihC of Borrelia recurrentis, Clone Brk2-47.1/BR2

Cat.No. ADG0160L (research box)
Article no.: 938321

Unit: 1,0 mg

Code: ADG0160L

Manufacturer: ImmBioMed GmbH & Co. KG - from the research box


  1. Borrelia recurrentis employs a novel multifunctional surface protein with anti-complement, anti-opsonic and invasive potential to escape innate immunity. Grosskinsky et al. PloS One. 2009; 4(3):e4858
  2. Human complement regulators C4b-binding protein and C1 esterase inhibitor interact with a novel outer surface protein of Borrelia recurrentis. Grosskinsky et al. PLoS Negl. Trop. Dis. 2011; 4(6):e698
  3. Immune evasion strategies of relapsing fever spirochetes. Rötterding and Kraiczy. Front. Immunol. 2020; 11:1560

Diese Webseite verwendet Cookies. Durch die Nutzung der Webseite stimmen Sie der Verwendung von Cookies zu. Datenschutzerklärung X